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Luohanguo has been used in parts of southern China as a fruit that enhances longevity. There is a high proportion of centenarians in the areas of south China where the fruit grows. This is probably why the fruit has gained its reputation as a longevity fruit.

Traditional Chinese medicine has long used luohanguo to treat obesity. Studies have shown that it has antioxidant properties though its ability to neutralize free radicals seems to be less than that of Vitamin E. It also has an anti-histaminic effect and has been used to treat heat stroke, chronic cough and sore throats.

Laboratory studies suggest that some of the compounds in the fruit like cucurbitane glycosides have a potential for fighting cancer cells. The mogrosides may also inhibit the growth of the Epstein Barr virus.